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The copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC). This is the "classic" click chemistry reaction that was discovered independently in 2002 by Meldal and coworkers and Sharpless and coworkers.

This is the reaction scheme for the copper(I)-catalyzed azide-alkyne cycloaddition, the “classic” click chemistry reaction that was discovered in 2002 independently by two different labs.

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